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NRAS p.G12D Reference Standard

CBP10314

詢 價(jià)
索取COA
產(chǎn)品描述
產(chǎn)品數(shù)據(jù)庫(kù)
Introduction 
Format Genomic DNA
Description NRAS G12D is a hotspot mutation that lies within a GTP-binding region of the Nras protein (UniProt.org). G12D confers a loss of function on Nras protein as indicated by decreased intrinsic GTPase activity, reduced sensitivity to GTPase-activating proteins, leading to accumulation of GTP-bound Nras, activation of downstream signaling, and transFormation of cultured cells (PMID: 19075190, PMID: 25252692).
   
Technical Data 
DNA Change c.35G>A
AA Change p.G12D
Mutation type Substitution - Missense
Zygosity Heterozygous
Allelic Frequency 66.67%
Transcript ENST00000369535
Cosmic ID COSM564
Chr position(GRCh37) chr1:115258747
Buffer Tris-EDTA
   
Product Information 
Intended Use Research Use Only
Unit Size 1ug
Concentration Download for COA
Purofication Download for COA
DNA electrophoresis Download for COA
Sanger sequencing
Storage 2-8℃
Expiry 36 months from the date of manufacture

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